تفاعل #339764

معادلة التفاعل

water

[4-(3-cyano-1-ethyl-6-isopropoxy-1H-indol-2-yl)-phenyl]-carbamic acid 2-chloro-ethyl ester

K2CO3

→

title compound

المردود 81.0%

1-ethyl-6-isopropoxy-2-[4-(2-oxo-oxazolidin-3-yl)-phenyl]-1H-indole-3-carbonitrile

المردود 81.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitate collected by filtration
2. 2
   غسيلwashed with hexane
3. 3
   أخرىdried in vacuo

الإجراء التجريبي

To a solution of [4-(3-cyano-1-ethyl-6-isopropoxy-1H-indol-2-yl)-phenyl]-carbamic acid 2-chloro-ethyl ester (30 mg, 0.07 mmol) in DMF (1 mL) is added aqueous K2CO3 (10 mg) and then stirred at 50° C. for 18 h. The reaction mixture is poured into cold water and the precipitate collected by filtration and washed with hexane and dried in vacuo to afford the title compound (21 mg, 81%).

المصدر