تفاعل #339713

معادلة التفاعل

Methyl 4-(3-cyano-1-ethyl-5-methoxy-1H-indol-2-yl)-benzoate

NaOH

THF

→

4-(3-cyano-1-ethyl-6-methoxy-1H-indol-2-yl)-benzoic acid

المردود 92.0%

المذيبات

H2O

H2O

ظروف التفاعل

المعالجة

1. 1
   غسيلether-washed
2. 2
   استخلاصis extracted into EtOAc
3. 3
   أخرىThe organic layer is dried
4. 4
   تركيزconcentrated

الإجراء التجريبي

Methyl 4-(3-cyano-1-ethyl-5-methoxy-1H-indol-2-yl)-benzoate (350 mg, 1.05 mmol), prepared as described in Example 1Ga step B, is combined with NaOH (40 mg, 1 mmol), H2O (0.8 mL), and THF (3.4 mL) and is heated at 80° C. for 1 hour. The reaction mixture is diluted in H2O and is then ether-washed. The aqueous layer is acidified with aqueous HCl, and is extracted into EtOAc. The organic layer is dried and concentrated to yield 4-(3-cyano-1-ethyl-6-methoxy-1H-indol-2-yl)-benzoic acid (311 mg, 92%) as a pure white solid.

المصدر