تفاعل #339550

معادلة التفاعل

hydrogen

acetic acid 4-(4-methoxy-but-1-ynyl)-pyridin-3-yl ester

quinoline

→

title compound

Acetic acid 4-(4-methoxy-butyl)-pyridin-3-yl ester

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe catalyst is removed by filtration
2. 2
   أخرىthe solvent is evaporated

الإجراء التجريبي

To a degassed solution of 9.9 mmol acetic acid 4-(4-methoxy-but-1-ynyl)-pyridin-3-yl ester and 0.51 mmol quinoline in 230 ml ethyl acetate is added 0.56 mmol 10% Pd/C. The suspension is vigorously stirred under an atmospheric pressure of hydrogen for 2 hours. The catalyst is removed by filtration and the solvent is evaporated. The title compound is obtained from the residue by means of flash chromatography (SiO2 60F) and identified based on its Rf value.

المصدر