تفاعل #339208

معادلة التفاعل

7,7,9,9-tetramethyl-1,4-dioxa-spiro[4.5]decan-8-one

HCl

→

2,2,6,6-tetramethyl-cyclohexane-1,4-dione

المردود 107.3%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىto remove most of the THF
3. 3
   استخلاصextracted with 3×EtOAc
4. 4
   تجفيفdried over MgSO4
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated

الإجراء التجريبي

To a solution of 7,7,9,9-tetramethyl-1,4-dioxa-spiro[4.5]decan-8-one (4.15 g, 0.019 mol, 1.0 eq.) in THF (60 mL) was added 1 N HCl (30 mL) and the resulting mixture was stirred at room temperature overnight, concentrated to remove most of the THF, extracted with 3×EtOAc. The organic layers were combined, dried over MgSO4, filtered and concentrated to give 2,2,6,6-tetramethyl-cyclohexane-1,4-dione as a white solid (3.43 g, >100%).

المصدر