تفاعل #339107

معادلة التفاعل

6-chloro-8-methyl-1H-benzo[d]-1,3-oxazine-2,4-dione

methyl carbazate

methanol

→

N-(2-amino-5-chloro-3-methylbenzoyl)-N′-methoxycarbonylhydrazine

المردود 60.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةto reflux for 3 hours
3. 3
   درجة الحرارةto cool to around room temperature
4. 4
   استخلاصthe mixture was extracted with ethyl acetate three times
5. 5
   تركيزThe resulting organic layer was concentrated under reduced pressure
6. 6
   غسيلthe residue was washed with toluene

الإجراء التجريبي

A mixture of 1.05 g of 6-chloro-8-methyl-1H-benzo[d]-1,3-oxazine-2,4-dione, 0.46 g of methyl carbazate and 20 ml of methanol was heated to reflux for 3 hours. After the reaction mixture was allowed to cool to around room temperature, water was poured thereto and the mixture was extracted with ethyl acetate three times. The resulting organic layer was concentrated under reduced pressure, and the residue was washed with toluene to obtain 0.77 g of N-(2-amino-5-chloro-3-methylbenzoyl)-N′-methoxycarbonylhydrazine of the formula:

المصدر