تفاعل #338962

معادلة التفاعل

5-phenyl-2-amino-pyridine

2,4′-dibromo acetophenone

sodium hydrogen carbonate

→

2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine

المردود 49.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained
2. 2
   درجة الحرارةunder heating for 3 hours
3. 3
   أخرىAfter completion of the reaction, separation
4. 4
   ترشيحwith filtration
5. 5
   غسيلresultant crystals were washed with water and methanol

الإجراء التجريبي

Dissolving crude 5-phenyl-2-amino-pyridine obtained and 8.0 g (29 mmol) of 2,4′-dibromo acetophenone into 100 milliliter of ethanol, adding 3.7 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 3 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining 5.4 g of 2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine (yield: 49%).

المصدر