تفاعل #338960

معادلة التفاعل

3,5-diphenyl-2-amino-pyridine

2,4′-dibromo acetophenone

sodium hydrogen carbonate

→

2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine

المردود 82.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained
2. 2
   درجة الحرارةunder heating for 7 hours
3. 3
   أخرىAfter completion of the reaction, separation
4. 4
   ترشيحwith filtration
5. 5
   غسيلresultant crystals were washed with water and methanol

الإجراء التجريبي

Dissolving crude 3,5-diphenyl-2-amino-pyridine obtained and 5.5 g (20 mmol) of 2,4′-dibromo acetophenone into 80 milliliter of ethanol, adding 3.0 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 7 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining 6.9 g of 2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine (yield: 82%).

المصدر