تفاعل #338613

معادلة التفاعل

1-Methoxyethylidene malononitrile

4-hydrazino-5,6-diphenyl-2-(trifluoromethyl)pyrimidine

→

title compound

5-amino-1-[5,6-diphenyl-2-(trifluoromethyl)pyrimidin-4-yl]-3-methyl-1H-pyrazole-4-carbonitrile

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solid that separated out from the reaction mixture
2. 2
   ترشيحwas filtered
3. 3
   غسيلwashed with methanol (5 ml)

الإجراء التجريبي

1-Methoxyethylidene malononitrile (0.17 g, 1.36 mmol) (prepared from malononitrile and triethyl orthoacetate by heating with acetic anhydride) was heated with 4-hydrazino-5,6-diphenyl-2-(trifluoromethyl)pyrimidine (0.15 g, 0.45 mmol) in methanol (6 ml), overnight at 60-65° C. The solid that separated out from the reaction mixture was filtered and washed with methanol (5 ml), to yield the title compound. 1H-NMR (DMSO-d6) δ: 1.97 (s, 3H), 6.97 (br, 2H, D2O exchangeable), 7.07 (d, 2H), 7.26-7.38 (m, 7H), 7.40-7.41 (m, 1H); MS m/z: 421.1 (M++1).

المصدر