تفاعل #337181

معادلة التفاعل

4-methylbenzo[d]thiazol-2-amine

1,1′-thiocarbonyldiimidazole

→

N-(4-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide

المردود 49.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction was cooled to room temperature
2. 2
   ترشيحthe precipitate was filtered
3. 3
   غسيلwashed with acetonitrile (2×50 mL)
4. 4
   أخرىThe yellow powder was dried in a vacuum oven (50° C.) for 1 hour

الإجراء التجريبي

To 4-methylbenzo[d]thiazol-2-amine (1.1 g, 6.7 mmol) in acetonitrile (30 mL) was added 1,1′-thiocarbonyldiimidazole (1.552 g, 8.71 mmol). The reaction mixture was stirred at 50° C. for 18 hours. The reaction was cooled to room temperature and the precipitate was filtered and washed with acetonitrile (2×50 mL). The yellow powder was dried in a vacuum oven (50° C.) for 1 hour to yield N-(4-methylbenzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide (900 mg, 3.28 mmol, 49% yield) and then used in the next step without any further purification or characterization.

المصدر