تفاعل #336944

معادلة التفاعل

7-Benzyl-3,7-dihydro-1H-purine-2,6-dione

sodium carbonate

1-iodopentane

→

desired product

المردود 44.0%

7-Benzyl-3-pentyl-3,7-dihydro-1H-purine-2,6-dione

المردود 44.0%

المذيبات

water

EtOAc

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe aqueous layer was extracted with EtOAc twice
2. 2
   أخرىThe combined organic layers were dried
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىThe resulting white solid was collected
6. 6
   أخرىdried in vacuum oven at 50° C. for 18 h

الإجراء التجريبي

7-Benzyl-3,7-dihydro-1H-purine-2,6-dione (5.0 g, 21 mmol) was mixed with sodium carbonate (3.3 g, 31 mmol) and 1-iodopentane (4.0 mL, 31 mmol) in DMF (60 mL). After being stirred at 40° C. for 18 h, the reaction mixture was diluted with water and EtOAc. The aqueous layer was extracted with EtOAc twice. The combined organic layers were dried, filtered and concentrated. The resulting white solid was collected and dried in vacuum oven at 50° C. for 18 h to provide the desired product (2.84 g, 44% yield). LCMS calculated for C17H21N4O2(M+H): 313.2. found: 313.2.

المصدر