تفاعل #336456

معادلة التفاعل

sodium hydroxide

1,5-dibromopentane

4-hydroxybenzophenone

→

4-[(5-bromopentyl)oxy]benzophenone

المردود 78.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic phase was separated
2. 2
   تجفيفdried over sodium sulphate
3. 3
   أخرىevaporated

الإجراء التجريبي

100 ml of a 10 percent aqueous sodium hydroxide solution were added to a solution of 34.5 g of 1,5-dibromopentane, 9.9 g of 4-hydroxybenzophenone and 1.6 g of tetrabutylammonium bromide in 100 ml of methylene chloride. The heterogeneous mixture was stirred at room temperature overnight. The organic phase was separated, dried over sodium sulphate and evaporated. By chromatography of the residue on silica gel with hexane:ethyl acetate (7:3) there were obtained 13.47 g (78%) of 4-[(5-bromopentyl)oxy]benzophenone as a colorless oil.

المصدر