تفاعل #336026

معادلة التفاعل

((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetic acid

N,N,N'-triethylethylenediamine

dicyclohexylcarbodiimide

→

N-(2- diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide

المردود 60.4%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   تركيزby concentrating it under reduced pressure
2. 2
   أخرىThe remaining residue was purified by chromatography on silica gel

الإجراء التجريبي

5.0 g of ((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetic acid were dissolved in 100 ml of tetrahydrofuran. 3.4 g (=4.2 ml) of N,N,N'-triethylethylenediamine and 5.3 g of dicyclohexylcarbodiimide were added to the solution, and the reaction mixture was stirred at room temperature for 24 hours. The mixture was worked up by concentrating it under reduced pressure. The remaining residue was purified by chromatography on silica gel using dichloromethane/methanol as the eluent. 4.8 g of N-(2- diethylaminoethyl)-N-(ethyl)-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)acetamide were obtained.

المصدر