تفاعل #334821

معادلة التفاعل

mannitol

acetone

→

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol

ظروف التفاعل

المعالجة

1. 1
   تركيزof concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask
2. 2
   أخرىthe acetone is evaporated by vacuum distillation at about 30° C
3. 3
   workup.ADDITIONThe remaining yellowish oil is diluted with an equal volume of cold water in order
4. 4
   أخرىto provide the crystalline product
5. 5
   ترشيحThe crystals are filtered
6. 6
   أخرىdried
7. 7
   أخرىused without further purification

الإجراء التجريبي

1,2:3,4:5,6-Tri-o-isopropylidene-d-mannitol is prepared by rapidly stirring with a mechanical stirrer, of 40 g of mannitol and 500 ml of anhydrous acetone in the presence of 4.0 ml of concentrated (18M) sulfuric acid as a catalyst for 24 hours in a 2 liter flask. The sulfuric acid is neutralized with about 6.8 g anhydrous sodium carbonate and the acetone is evaporated by vacuum distillation at about 30° C. The remaining yellowish oil is diluted with an equal volume of cold water in order to provide the crystalline product. The crystals are filtered, dried, and used without further purification.

المصدر