تفاعل #3348

معادلة التفاعل

2-dimethylaminobenzylchloride hydrochloride

2-benzylthio-5,5-dimethylimidazolin-4-thione

→

2-benzylthio-4-(2-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   workup.ADDITIONThe residue was treated
3. 3
   أخرىpurified by column chromatography (CHCl3)
4. 4
   أخرىRecrystallization from diethyl ether-n-hexane

الإجراء التجريبي

Initially, 0.65 g of 2-dimethylaminobenzylchloride hydrochloride was added to a solution of 0.7 g of 2-benzylthio-5,5-dimethylimidazolin-4-thione in 20 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization from diethyl ether-n-hexane gave 2-benzylthio-4-(2-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole in the form of a needle-like crystal. The yield of this compound was 0.75 g with a yield ratio of 72.2%, and the melting point was 91°-92° C.

المصدر