تفاعل #3347

معادلة التفاعل

benzylbromide

5,5-dimethyl-2,4-dithiohydantoin

→

2-benzylthio-5,5-dimethylimidazolin-4-thione

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   workup.ADDITIONThe residue was treated
3. 3
   أخرىpurified by column chromatography (CHCl3)
4. 4
   أخرىRecrystallization from diethyl ether-n-hexane

الإجراء التجريبي

Initially, 1.91 mL of benzylbromide was added to a solution of 1.6 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization from diethyl ether-n-hexane gave 2-benzylthio-5,5-dimethylimidazolin-4-thione in the form of a needle-like crystal. The yield of this compound was 0.87 g with a yield ratio of 34.8%, and the melting point was 133°-134° C.

المصدر