تفاعل #3346

معادلة التفاعل

4-dimethylaminobenzylchloride hydrochloride

5,5-dimethyl-2,4-dithiohydantoin

→

desired compound

2,4-bis-(4-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe reaction mixture was treated
2. 2
   أخرىpurified by column chromatography (CHCl3)
3. 3
   أخرىRecrystallization
4. 4
   أخرىform diethyl ether-n-hexane

الإجراء التجريبي

Initially, 3.2 g of 4-dimethylaminobenzylchloride hydrochloride was added to a solution of 1 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization form diethyl ether-n-hexane gave the desired compound in the form of a needle-like crystal. The yield of this compound was 1.9 g with a yield ratio of 71.2%, and the melting point was 91°-92° C.

المصدر