تفاعل #3343

معادلة التفاعل

3-dimethylaminobenzylchloride hydrochloride

5,5-dimethyl-2,4-dithiohydantoin

sodium methoxide

→

2,4-bis(3-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   workup.ADDITIONThe residue was treated
3. 3
   أخرىchromatographed on a column of silica gel (CHCl3)

الإجراء التجريبي

Initially, 2.94 g of 3-dimethylaminobenzylchloride hydrochloride was added to a mixture of 1.6 g of 5,5-dimethyl-2,4-dithiohydantoin and 1.3 g of sodium methoxide in 50 mL of methanol (MeOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 56, and chromatographed on a column of silica gel (CHCl3). From the earlier fractions, 2,4-bis(3-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole was isolated, in the form of a syrup. The yield of this compound was 0.31 g with a yield ratio of 7.4%.

المصدر