تفاعل #334229

معادلة التفاعل

3-methylpiperidine

4-chlorobutyronitrile

→

4-(3-methylpiperidino)-butyronitrile

المردود 70.3%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   أخرىthe precipitate was removed by filtration
2. 2
   أخرىThe residue from the evaporation
3. 3
   workup.DISTILLATIONwas purified by distillation under reduced pressure

الإجراء التجريبي

In a solution under reflux of 58.6 ml (0.50 mole) of 3-methylpiperidine in 65 ml of benzene, were run in 25 minutes 27.2 g (0.25 mole) of 4-chlorobutyronitrile Reflux was continued for 2h, the precipitate was removed by filtration and the filtrate brought to dryness under reduced pressure. The residue from the evaporation was purified by distillation under reduced pressure to give 29.2 g (yields=70.3%) of 4-(3-methylpiperidino)-butyronitrile which was in the form of a colourless oil. Boiling point 5-6 mmHg =100° C.

المصدر