تفاعل #332492

معادلة التفاعل

Dibenzylamine

lithium bromide

(S)-epichlorohydrin

→

colorless oil

المردود 91.4%

(S)-1-chloro-3-(dibenzylamino)propan-2-ol

المردود 91.4%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   workup.WAITThe reaction went on at room temperature (32° C.) for 2 hours
2. 2
   ترشيحFiltered
3. 3
   أخرىthe solvent was evaporated

الإجراء التجريبي

Dibenzylamine (39.4 g, 0.20 mol) and lithium bromide (1.7 g, 20 mmol) were added to 100 mL ethyl acetate and stirred for 30 minutes. (S)-epichlorohydrin (21 g, 0.23 mol) was then added. The reaction went on at room temperature (32° C.) for 2 hours. Filtered, and the solvent was evaporated to provide 53 g of colorless oil with 90% yield.

المصدر