تفاعل #332491

معادلة التفاعل

Dibenzylamine

(S)-epichlorohydrin

→

colorless oil

المردود 96.6%

(S)-1-chloro-3-(dibenzylamino)propan-2-ol

المردود 96.6%

المذيبات

methylene dichloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature (30° C.) for 5 hours
2. 2
   ترشيحFiltered
3. 3
   أخرىthe solvent was evaporated

الإجراء التجريبي

Dibenzylamine (39.4 g, 0.20 mol) and calcium chloride (1 g, 9 mmol) were added to 100 mL of methylene dichloride and stirred for 30 minutes. (S)-epichlorohydrin (21 g, 0.23 mol) was then added. The mixture was stirred at room temperature (30° C.) for 5 hours. Filtered, and the solvent was evaporated to provide 56 g of colorless oil in 95% yield.

المصدر