تفاعل #331706

معادلة التفاعل

Methanesulphonyl chloride

N,N-dimethyl-1,3-phenylenediamine

sodium hydroxide

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material

المردود 79.0%

N-[3-(dimethylamino)phenyl]methanesulphonamide

المردود 79.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture was extracted with chloroform (3×15 cm3)
2. 2
   تجفيفThe combined extracts were dried over sodium sulphate
3. 3
   ترشيحfiltered
4. 4
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

Methanesulphonyl chloride (838 mg, 7.35 mmol) was added slowly to a cooled solution (5° C.) of N,N-dimethyl-1,3-phenylenediamine (1.00 g, 7.35 mmol) and sodium hydroxide (5M, 1.5 cm3) in water (10 cm3). The reaction was allowed to warm to room temperature overnight. The mixture was extracted with chloroform (3×15 cm3). The combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (1:20 methanol/dichloromethane) gave the target material as a brown oil (1.24 g, 79%).

المصدر