تفاعل #331250

معادلة التفاعل

1-aminocyclohexanecarboxylic acid

thionyl chloride

ether

→

Methyl 1-aminocyclohexanecarboxylate hydrochloride

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىis sparged hydrogen chloride for 2 minutes
2. 2
   أخرىobtained
3. 3
   درجة الحرارةthe reaction medium is refluxed for 6 hours
4. 4
   درجة الحرارةAfter cooling
5. 5
   تركيزthe mixture is concentrated under reduced pressure
6. 6
   أخرىthe residue obtained
7. 7
   أخرىto precipitate 2.3 g of methyl 1-aminocyclohexanecarboxylate hydrochloride in the form of a white powder

الإجراء التجريبي

To a suspension of 2 g (14 mmol) of 1-aminocyclohexanecarboxylic acid in 20 mL of methanol is sparged hydrogen chloride for 2 minutes. 1.2 mL (16.8 mmol) of thionyl chloride are added to the solution obtained and the reaction medium is refluxed for 6 hours. After cooling, the mixture is concentrated under reduced pressure and the residue obtained is taken up in 5 mL of methanol. 50 mL of ether are added so as to precipitate 2.3 g of methyl 1-aminocyclohexanecarboxylate hydrochloride in the form of a white powder.

المصدر