تفاعل #329872

معادلة التفاعل

4-chlorobromobenzene

3-(R)-Methyl-piperazine-1-carboxylic acid tert-butyl ester

BINAP

sodium-t-butoxide

→

title compound

4-(4-Chloro-phenyl)-3-(R)-methyl-piperazine-1-carboxylic acid tert-butyl ester

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   غسيلwashed with saturated aqueous sodium bicarbonate and brine
3. 3
   تجفيفdried over magnesium sulfate

الإجراء التجريبي

To a mixture of 4-chlorobromobenzene (0.53 g, 2.75 mmol) and 3-(R)-Methyl-piperazine-1-carboxylic acid tert-butyl ester (0.5 g, 2.5 mmol) in toluene (20 mL) was added tris(dibenzylideneacetone) dipalladium(0) (0.029 g, 0.032 mmol), BINAP (0.058 g, 0.093 mmol) and sodium-t-butoxide (1.01 g, 10.5 mmol). The resulting mixture was heated 110° C. for 20 h. The solvent was evaporated and the residue was taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate and brine and dried over magnesium sulfate. Column chromatography (10% ethyl acetate/hexane) provided the title compound.

المصدر