تفاعل #329296

معادلة التفاعل

sodium ethylate

2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester

→

2-ethoxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester

المردود 97.0%

المذيبات

EtOH

water

EtOAc

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic phase was separated
2. 2
   غسيلwashed with a 4N aq. NH4Cl sol.
3. 3
   تجفيفdried over MgSO4
4. 4
   تركيزconcentrated in a vacuum

الإجراء التجريبي

1.2 g (17.8 mmol) sodium ethylate was added to a solution of 5.1 g (16.1 mmol) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester in EtOH (20 ml) at RT. The RS was subsequently heated to 60° C. for 4 h and then stirred for 16 h at RT. The solution was then diluted with water and EtOAc. The organic phase was separated and washed with a 4N aq. NH4Cl sol., dried over MgSO4 and concentrated in a vacuum. 5.1 g (15.6 mmol, 97%) 2-ethoxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester was obtained as a residue. The raw product was further converted without additional purification.

المصدر