تفاعل #327484

معادلة التفاعل

DIPEA

HOAt

DIC

2-(Aminomethyl)pyridine

DIPEA

Dimethylmalonic acid

Chlorotrityl chloride

→

title compound

2,2-Dimethyl-N-pyridin-2-ylmethylmalonamic acid

المذيبات

DCM

NMP

NMP

DCM NMP

DCM

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   workup.ADDITIONadded to the resin
3. 3
   ترشيحThe resin was filtered
4. 4
   غسيلwashed with DCM:MeOH:DIPEA (17:2:1), DCM, NMP og DCM (2×25 mL of each)
5. 5
   workup.WAITThe resin was swelled in NMP for 20 mins
6. 6
   ترشيحfiltered
7. 7
   workup.STIRRINGthe resin was shaken for 90 min at RT
8. 8
   workup.STIRRINGThe resin was shaken for overnigth
9. 9
   ترشيحThe resin was filtered
10. 10
    غسيلwashed with NMP (5×20 mL) and DCM (10×20 mL)
11. 11
    workup.ADDITIONTFA/TIS/water (95:2.5:2.5; 30 mL) was added to the resin and it
12. 12
    workup.WAITwas shaked for 1 hr
13. 13
    ترشيحfiltered
14. 14
    تركيزconcentrated in vacuo

الإجراء التجريبي

Chlorotrityl chloride resin (2.3 g, 3.0 mmol) was swelled in DCM for 20 mins and filtered. Dimethylmalonic acid (2 eq; 6.0 mmol; 793 mg) was dissolved i DCM:NMP 1:1 (10 mL) and added to the resin followed by DIPEA (6 eq; 18.0 mmol; 3.14 mL) and DCM (10 mL). The resin was shaken overnight at RT. The resin was filtered and washed with DCM:MeOH:DIPEA (17:2:1), DCM, NMP og DCM (2×25 mL of each). The resin was swelled in NMP for 20 mins and filtered. HOAt (3 eq; 9.0 mmol; 1.23 g), DIC (3 eq; 9.0 mmol; 1.40 mL) and NMP (25 mL) was added and the resin was shaken for 90 min at RT. The resin was filtrered and 2-(Aminomethyl)pyridine (2 eq; 6 mmol; 659 mg), DIPEA (4 eq; 6.0 mmol; 2.09 mL), and NMP (10 mL) was added. The resin was shaken for overnigth. The resin was filtered and washed with NMP (5×20 mL) and DCM (10×20 mL). TFA/TIS/water (95:2.5:2.5; 30 mL) was added to the resin and it was shaked for 1 hr, filtered and concentrated in vacuo to yield the title compound.

المصدر