تفاعل #327059

معادلة التفاعل

mixture

7-bromo-4-(4-nitrophenyl)-1H-indazol-3-amine

N,N-dimethylacrylamide

triethylamine

→

desired product

(2E)-3-[3-amino-4-(4-nitrophenyl)-1H-indazol-7-yl]-N,N-dimethylacrylamide

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىThe residue was purified by flash column chromatography on silica gel with 3% methanol/dichloromethane

الإجراء التجريبي

A mixture of Example 84B (165 mg), N,N-dimethylacrylamide (0.102 mL), triethylamine (0.207 mL), and Pd(o-tol3P)2Cl2 (30 mg) in THF (2 mL) in a sealed tube was heated in a Smith Synthesizer microwave oven (at 300 W) to 150° C. and concentrated. The residue was purified by flash column chromatography on silica gel with 3% methanol/dichloromethane to provide 163 mg of the desired product. MS (ESI(+)) m/e 352 (M+H)+.

المصدر