تفاعل #326099

معادلة التفاعل

(S)-3-(3′-chloro-biphenyl-4-yl)-2-((S)-1-ethoxycarbonyl-ethoxy)-propionic acid benzyl ester

→

(S)-3-(3′-chloro-biphenyl-4-yl)-2-((S)-1-ethoxycarbonyl-ethoxy)-propionic acid

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 30 mins
2. 2
   ترشيحThe reaction was filtered off the catalyst
3. 3
   تركيزconcentrated
4. 4
   أخرىThe residue was purified by HPLC (15 to 70% ACN—H2O (0.1% TFA))
5. 5
   أخرىto give oil

الإجراء التجريبي

A mixture of (S)-3-(3′-chloro-biphenyl-4-yl)-2-((S)-1-ethoxycarbonyl-ethoxy)-propionic acid benzyl ester and 10% Pd/C wet in EtOAc was hydrogenated under H2 balloon for 30 mins. The reaction was filtered off the catalyst and concentrated. The residue was purified by HPLC (15 to 70% ACN—H2O (0.1% TFA)) to give oil: 128 mg. HPLC retention time=1.07 minutes (condition C); MS (m−1)=375.

المصدر