تفاعل #325857

معادلة التفاعل

aluminum chloride

trifluoroacetyl chloride

vinylidene chloride

→

4,4-dichloro-1,1,1-trifluoro-3-buten-2-one

المذيبات

water

dichloromethane

dichloro-methane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe temperature of the reaction mixture below −30° C
2. 2
   workup.STIRRINGThe reaction mixture was stirred an additional 2 h at −50° C.
3. 3
   درجة الحرارةwarmed gradually to room temperature
4. 4
   استخلاصthe aqueous layer was extracted with dichloromethane
5. 5
   تجفيفdried (MgSO4)
6. 6
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of aluminum chloride (3.0 g, 22.5 mmol) in dichloromethane (100 mL) was added dropwise a solution of trifluoroacetyl chloride (3 g, 22.6 mmol) in dichloro-methane (5 mL) while keeping the temperature of the reaction mixture below −30° C. The reaction mixture was stirred for 15 minutes at −50° C. Then a solution of vinylidene chloride (2.2 g, 22.7 mmol) in dichloromethane (10 mL) was added dropwise over 2 h to the reaction mixture. The reaction mixture was stirred an additional 2 h at −50° C. and then warmed gradually to room temperature. The reaction mixture was diluted with water, and the aqueous layer was extracted with dichloromethane. The organic layers were combined, dried (MgSO4), and concentrated under reduced pressure to give 4,4-dichloro-1,1,1-trifluoro-3-buten-2-one as an oil which was used for the next step without further purification.

المصدر