تفاعل #325642

معادلة التفاعل

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene

N-methylpiperazine

→

compound

1-Methyl-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazine

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   workup.ADDITIONthe filtrate was treated with 1-chlorobutane
3. 3
   استخلاصextracted with 2N HCl (100 ml)
4. 4
   workup.ADDITIONThe acidic solution was treated with 5N NaOH (6 ml)
5. 5
   استخلاصthen extracted with EtOAc
6. 6
   أخرىThe organic layer was removed
7. 7
   تجفيفdried over MgSO4
8. 8
   تركيزconcentrated

الإجراء التجريبي

2-Bromomethyl-4-nitro-1-pentafluoroethyl-benzene (2.6 g) was added to N-methylpiperazine (5 ml) and stirred at RT for 3 h. The mixture was filtered and the filtrate was treated with 1-chlorobutane, extracted with 2N HCl (100 ml). The acidic solution was treated with 5N NaOH (6 ml) then extracted with EtOAc. The organic layer was removed, dried over MgSO4 and concentrated to give the compound as an oil.

المصدر