تفاعل #325533

معادلة التفاعل

sodium hydrogencarbonate

2,2-dimethyl-1-propanol

chloroform

3-bromobenzenesulfonyl chloride

→

title compound

المردود 108.1%

2,2-Dimethylpropyl 3-bromobenzenesulfonate

المردود 108.1%

المذيبات

water

pyridine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةUnder cooling in an ice bath
2. 2
   استخلاصthe obtained mixture was then extracted with chloroform
3. 3
   غسيلThe organic layer was washed with a saturated saline
4. 4
   تجفيفwas then dried over anhydrous sodium sulfate
5. 5
   تركيزfollowed by vacuum concentration
6. 6
   غسيلThe obtained solid was washed with n-hexane

الإجراء التجريبي

Under cooling in an ice bath, 2,2-dimethyl-1-propanol (1.55 g) was added to a chloroform (20 mL) solution that contained 3-bromobenzenesulfonyl chloride (3.00 g) and pyridine (1.86 g), and the obtained solution was then stirred at a room temperature for 60 hours. Thereafter, water and a saturated sodium hydrogencarbonate aqueous solution were added to the reaction solution, and the obtained mixture was then extracted with chloroform. The organic layer was washed with a saturated saline, and was then dried over anhydrous sodium sulfate, followed by vacuum concentration. The obtained solid was washed with n-hexane, so as to obtain the title compound (3.90 g) in the form of a colorless solid.

المصدر