تفاعل #3255

معادلة التفاعل

sodium

2-dimethylaminoethanol

6-chloro-9,10-methylenedioxy-7H-indeno[2,1-c]quinoline-7-on

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title compound

المردود 68.1%

6-(2-dimethylaminoethoxy)-9,10-methylenedioxy-7H-indeno[2,1-c]quinoline-7-on

المردود 68.1%

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained in reference example 2
2. 2
   استخلاصextracted with chloroform
3. 3
   تجفيفThe chloroform layer was dried over magnesium sulfate
4. 4
   أخرىevaporated
5. 5
   أخرىThe residue was purified by silica gel column chromatography (eluent; chloroform:methanol=10:1(v/v)) and
6. 6
   أخرىcrystallized from ethyl acetate

الإجراء التجريبي

To a solution prepared with sodium (1.78 g, 77.4 mmol) and 2-dimethylaminoethanol (80 ml, 796 mmol) was added 6-chloro-9,10-methylenedioxy-7H-indeno[2,1-c]quinoline-7-on (8 g, 25.8 mmol) obtained in reference example 2, and the mixture was stirred with heat at 60° C. for 24 hours. The reaction mixture was poured into ice water and extracted with chloroform. The chloroform layer was dried over magnesium sulfate and evaporated. The residue was purified by silica gel column chromatography (eluent; chloroform:methanol=10:1(v/v)) and crystallized from ethyl acetate to give 6.37 g (yield: 68.1%) of title compound. The physicochemical properties thereof are shown in table 2.

المصدر