تفاعل #325450

معادلة التفاعل

4-(2-Cyano-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Ammonium formate

→

title compound

المردود 74.5%

4-(2-Cyano-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

المردود 74.5%

المذيبات

—

IMS

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture heated
2. 2
   درجة الحرارةat reflux for 0.5 hour
3. 3
   درجة الحرارةto cool
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent removed by evaporation

الإجراء التجريبي

4-(2-Cyano-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.2 g) was dissolved in IMS (15 mL) and palladium on carbon (10%; 0.08 g) in water (0.5 mL) was added. Ammonium formate (0.3 g) was added and the mixture heated at reflux for 0.5 hour. The mixture was allowed to cool, filtered and the solvent removed by evaporation to give the title compound as a clear colourless oil (0.15 g). LCMS m/z 287.3[M+H]+. R.T.=4.63 min (Analytical Method 4).

المصدر