تفاعل #325376

معادلة التفاعل

2-ethyl-benzo[d][1,3]oxazin-4-one

propylamine

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product

المردود 29.1%

2-Ethyl-3-propyl-3H-quinazolin-4-one

المردود 29.1%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude product was purified by column chromatography (10-40% ethyl acetate-hexanes)

الإجراء التجريبي

A mixture of 2-ethyl-benzo[d][1,3]oxazin-4-one (541 mg, 3.1 mmol) and propylamine (254 μL, 3.1 mmol) were heated to 110° C. for 1 hour. The crude product was purified by column chromatography (10-40% ethyl acetate-hexanes) to yield the product as a white solid (195 mg, 29%). 1H NMR (CDCl3) δ 1.03 (t, 3H, J=7.4 Hz), 1.41 (t, 3H, J=7.3 Hz), 1.76 (sex, 2H, J=7.7 Hz), 2.86 (q, 2H, J=7.4 Hz), 4.05 (t, 2H, J=7.9 Hz), 7.42 (t, 1H, J=8.1 Hz), 7.63 (d, 1H, J=7.7 Hz), 7.70 (t, 1H, J=7.7 Hz), 8.24 (d, 1H, J=8.1 Hz).

المصدر