تفاعل #324584

معادلة التفاعل

1-(5-bromo-2-fluorophenyl)-1-propanol

1-(5-Bromo-2-fluorophenyl)-1-propanol

aluminium oxide

pyridinium chlorochromate

→

crude title compound

1-(5-Bromo-2-fluorophenyl)-1-propanone

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was then filtered through silica gel (200 g, 0.06-0.2 mm) which
2. 2
   غسيلwas thoroughly washed with dichloromethane (1000 ml)
3. 3
   غسيلThe combined filtrates were washed with brine
4. 4
   تجفيفdried over sodium sulfate
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

A mixture of 10 g (42.9 mmol) 1-(5-bromo-2-fluorophenyl)-1-propanol (Example 5A), 8.75 g (85.8 mmol) neutral aluminium oxide and 18.5 g (85.8 mmol) pyridinium chlorochromate in dichloromethane (100 ml) was stirred at room temperature for 4 h. The mixture was then filtered through silica gel (200 g, 0.06-0.2 mm) which was thoroughly washed with dichloromethane (1000 ml). The combined filtrates were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The crude title compound thus obtained (8.6 g, 87% of th.) was used in the next step without further purification.

المصدر