تفاعل #324444

معادلة التفاعل

NH4Cl

5-trifluoromethyl-furan-2-carbaldehyde

MeMgBr

→

title compound

المردود 97.8%

1-(5-Trifluoromethyl-furan-2-yl)-ethanol

المردود 97.8%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture extracted with EtOAc (2×)
2. 2
   غسيلThe combined organics were washed with brine
3. 3
   أخرىdried

الإجراء التجريبي

To 5-trifluoromethyl-furan-2-carbaldehyde (0.76 g, 4.6 mmol) in THF (20 mL) at 0° C. was added MeMgBr (3M in Et2O, 3 mL, 6 mmol) dropwise over 1 h. After an additional 1 h, ½ saturated NH4Cl (aq.) was added and the mixture extracted with EtOAc (2×). The combined organics were washed with brine and dried to give 0.81 g (97%) of the title compound. 1H NMR (CDCl3): 6.74-6.73 (m, 1H), 6.32-6.31 (m, 1H), 4.91 (q, J=6.5 Hz, 1H), 1.57 (d, J=6.6 Hz, 3H).

المصدر