تفاعل #324417

معادلة التفاعل

2-(4-methoxyphenyl)propanoic acid

thionyl chloride

→

2-(4-methoxyphenyl)propanoyl chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe solution was heated
2. 2
   درجة الحرارةto reflux for 27 hours
3. 3
   تركيزthe mixture was concentrated under reduced pressure

الإجراء التجريبي

Under an argon atmosphere, 2-(4-methoxyphenyl)propanoic acid (synthesized by the process of I. Shiina, et al., Eur. J. Org. Chem., 5887-5890 (2008)) (1.20 g, 6.66 mmol) was dissolved in thionyl chloride (6.00 mL, 82.6 mmol) and the solution was heated to reflux for 27 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 2-(4-methoxyphenyl)propanoyl chloride (16) as a colorless oil. The product was used in the following reaction without further purification.

المصدر