تفاعل #324369

معادلة التفاعل

N-[3-(dimethylamino)propyl]methacrylamide

butanesultone

acetone

methanol

→

4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium

المردود 85.5%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cooling, to the reaction mixture
2. 2
   ترشيحThe crystals deposited were collected by filtration
3. 3
   غسيلthoroughly washed with acetone

الإجراء التجريبي

In 380 ml of acetonitrile were dissolved 130 g (0.764 mol) of N-[3-(dimethylamino)propyl]methacrylamide, 104 g of butanesultone and 234 mg of 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy and the solution was heated at 70° C. for 6 hours. After allowing to cooling, to the reaction mixture were added 1,350 ml of acetone and 150 ml of methanol and the mixture was stirred at room temperature for one hour. The crystals deposited were collected by filtration and thoroughly washed with acetone to obtain 200.0 g (yield: 85%) of 4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium.

المصدر