تفاعل #324356

معادلة التفاعل

aniline

N,N-diisopropylethylamine

propane sultone

→

di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate

المردود 94.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated
2. 2
   workup.ADDITIONethylacetate was added
3. 3
   ترشيحThe precipitated DIPEA bromide was filtered off
4. 4
   أخرىthe filtrate was evaporated
5. 5
   workup.ADDITIONThe residue was treated with ether

الإجراء التجريبي

A mixture of aniline (7 mmol), N,N-diisopropylethylamine (DIPEA, 18 mmol) and propane sultone (16 mmol) was heated in a pressure tube in 10 mL of acetonitrile at 120-130° C. for 9 h under argon atmosphere. The solvent was evaporated and ethylacetate was added. The precipitated DIPEA bromide was filtered off and the filtrate was evaporated. The residue was treated with ether to give di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate as a white or pinky-white solid. Yield: 94%.

المصدر