تفاعل #323685

ord-aa5ec83584744ae8b5c520be6f8790c3

معادلة التفاعل

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)O
triacontanoic acid
CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
dibenzyl N-(N-tert-butoxycarbonyl-L-valyl)-L-glutamate
→
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)C(C)C
dibenzyl N-(N-triacontanoyl-L-valyl)-L-glutamate
المردود 50.0%

المتفاعلات

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)O
triacontanoic acid
CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCC(=O)OCc1ccccc1)C(=O)OCc1ccccc1
dibenzyl N-(N-tert-butoxycarbonyl-L-valyl)-L-glutamate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Starting from triacontanoic acid (452 mg) and dibenzyl N-(N-tert-butoxycarbonyl-L-valyl)-L-glutamate (526 mg), dibenzyl N-(N-triacontanoyl-L-valyl)-L-glutamate (430 mg) was obtained as powder according to a similar manner to that of Example 28.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04643990uspto-grants-1987_02