تفاعل #323461

معادلة التفاعل

1,1,3,3-tetramethoxy-propane

2-hydrazino-4(3H)-quinazolinone

water

hydrochloric acid

→

2-(1H-pyrazol-1-yl)-4(3H)-quinazolinone

المردود 70.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe desired product precipitates after a short time from the solution
2. 2
   أخرىinitially formed
3. 3
   أخرىAfter a reaction of one hour in total at 40° C.

الإجراء التجريبي

A mixture of 35.2 g (0.2 mole) of 2-hydrazino-4(3H)-quinazolinone, 250 ml of water, 30 ml of methanol and 36.6 ml of concentrated hydrochloric acid is stirred with 36.08 g (0.22 mole) of 1,1,3,3-tetramethoxy-propane at 40° C. The desired product precipitates after a short time from the solution initially formed. After a reaction of one hour in total at 40° C., 29.8 g of 2-(1H-pyrazol-1-yl)-4(3H)-quinazolinone (melting point 148°-50°) are isolated.

المصدر