تفاعل #322980

ord-aed52c31015a449c876ee2d44d3e8050

معادلة التفاعل

N=C(N)NCCC[C@H](N)C(=O)O
Arginine
O=C1N=C([O-])NC1(c1ccccc1)c1ccccc1.[Na+]
phenytoin sodium
→
N=C(N)NCCC[C@H](N)C(=O)O.O=C1N=C([O-])NC1(c1ccccc1)c1ccccc1.[Na+]
Phenytoin Sodium Arginine

المتفاعلات

N=C(N)NCCC[C@H](N)C(=O)O
Arginine
O=C1N=C([O-])NC1(c1ccccc1)c1ccccc1.[Na+]
phenytoin sodium

الكواشف

[Na+].[OH-]
sodium hydroxide

المذيبات

O
water

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    workup.DISSOLUTIONthe dissolution of the solid
  2. 2
    workup.STIRRINGAfter about 30 min. stirring

الإجراء التجريبي

Arginine (1.6 g, 4.6 mmol) was dissolved in 20 ml water and added to 1.25 g (4.6 mmol) phenytoin sodium with stirring. One drop of 10 N sodium hydroxide solution was added to complete the dissolution of the solid. After about 30 min. stirring, the pH of the solution stabilized at 11.4-11.6.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US04642316uspto-grants-1987_02