تفاعل #322747

معادلة التفاعل

N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulfonamide

potassium hydroxide

hydrochloric acid

→

desired product

المردود 86.4%

N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-carboxybenzenesulfonamide

المردود 86.4%

المذيبات

water

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solid was filtered
2. 2
   غسيلwashed with water
3. 3
   أخرىdried

الإجراء التجريبي

N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulfonamide (15 g) was added to a warm solution of 7.5 g of potassium hydroxide in 7.5 ml of water and 60 ml of ethanol. The mixture was stirred at room temperature overnight and then poured into dilute hydrochloric acid. The solid was filtered, washed with water and dried to afford 12.5 g of the desired product: m.p. 155°-157° C. IR (cm-1) 3000, 1720.

المصدر