تفاعل #322186

معادلة التفاعل

2-amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine

2-Amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine

methanethiol sodium salt

tris[2-(2-methoxyethoxy)ethyl]amine

→

title compound

المردود 52.0%

2-Amino-4-chloro-5-(2,4-dichlorophenyl)-6-methylthio pyrimidine

المردود 52.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe cooled reaction mixture
2. 2
   ترشيحwas filtered
3. 3
   أخرىevaporated
4. 4
   أخرىthe residue purified by flash column chromatography

الإجراء التجريبي

A mixture of 2-amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine (0.5 g) (Example 32) THF (15 ml), methanethiol sodium salt (0.113 g), copper powder (0.05g) and tris[2-(2-methoxyethoxy)ethyl]amine (0.1 g) was heated in an autoclave at 180° C. for 18 hours. The cooled reaction mixture was filtered, evaporated and the residue purified by flash column chromatography to give the title compound (0.262 g, 52%), mp. 201°-202° C. (softens at 196° C.). Microanalysis: Calcd: C, 41.19; H, 2.50; N, 13.10; Found: C, 41.10; H, 2.52; N, 12.77.

المصدر