تفاعل #321882

معادلة التفاعل

benzo[b]thiophene

bromine

→

3-bromobenzo[b]thiophene

المذيبات

carbon tetrachloride

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAdd, by dropwise addition
2. 2
   أخرىQuench with a 1M solution of sodium thiosulfate
3. 3
   أخرىseparate the organic phase
4. 4
   استخلاصExtract the aqueous phase with carbon tetrachloride
5. 5
   تجفيفdry (MgSO4)
6. 6
   أخرىEvaporate the solvent in vacuo
7. 7
   workup.DISTILLATIONpurify by distillation

الإجراء التجريبي

Dissolve benzo[b]thiophene (23g, 0.170mmol) in carbon tetrachloride (80mL). Add, by dropwise addition, a solution of bromine (26.85g, 0.168mmol) in carbon tetrachloride (30mL) and stir at room temperature for 2 days. Quench with a 1M solution of sodium thiosulfate and separate the organic phase. Extract the aqueous phase with carbon tetrachloride, combine the organic phases and dry (MgSO4). Evaporate the solvent in vacuo and purify by distillation to give 3-bromobenzo[b]thiophene as a pale yellow liquid (17.33g, 48%); bp 64°-72° C.@0.02mm Hg.

المصدر