تفاعل #321819

معادلة التفاعل

4-chloro-5-methoxy-6-methoxymethylpyrimidine

4-iso-butylidene-cyclohexylamine

triethylamine

→

4-(4-Isobutylidenecyclohexylamino)-5-methoxy-6-methoxymethylpyrimidine

المذيبات

water toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter cooling
2. 2
   أخرىthe organic phase was dried
3. 3
   أخرىevaporated on a rotary evaporator
4. 4
   أخرىPurification by chromatography (silica gel/ethyl acetate)
5. 5
   أخرىgave 2.2 g (36% of theory) of a virtually colorless oil

الإجراء التجريبي

3.8 g (20 mmol) of 4-chloro-5-methoxy-6-methoxymethylpyrimidine (DE-A 4 116 089), 3.1 g (20 mmol) of 4-iso-butylidene-cyclohexylamine and 3.0 g (30 mmol) of triethylamine were stirred for 3 hours without solvent at 80°-90° C. After cooling, the mixture was taken up in water/toluene, and the organic phase was dried and evaporated on a rotary evaporator. Purification by chromatography (silica gel/ethyl acetate) gave 2.2 g (36% of theory) of a virtually colorless oil.

المصدر