تفاعل #3215

معادلة التفاعل

6-iodo-1H-indole-2,3-dione

water

→

title compound

المردود 81.8%

7-Iodo-2H-3,1-benzoxazine-2,4(1H)-dione

المردود 81.8%

المذيبات

acetic acid

acetic anhydride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile maintaining the temperature of the reaction mixture at 80°-90° C
2. 2
   درجة الحرارةcooled
3. 3
   ترشيحThe resulting mixture was filtered
4. 4
   أخرىthe collected solids dried

الإجراء التجريبي

To a stirred warm (80° C.) solution of 6-iodo-1H-indole-2,3-dione (3.0 g, 11 mM) in acetic acid (10 mL) and acetic anhydride (10 mL) was added in small portions chromium trioxide (1.83 g, 18.3 mM) while maintaining the temperature of the reaction mixture at 80°-90° C. The reaction mixture was then heated at 80° C. for 10 min, cooled and poured into water. The resulting mixture was filtered and the collected solids dried to provide the title compound as a yellow solid (2.6 g, 81.8%); MS(CI): 290 (M+H).

المصدر