تفاعل #321352

معادلة التفاعل

NaHCO3

iodoacetyl chloride

5-Aminosalicylamide

HCl

→

5-(iodoacetamido)salicylamide

المردود 101.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added dropwise over 15 min
2. 2
   أخرىThe precipitate is collected
3. 3
   تجفيفdried in vacuo over NaOH pellets

الإجراء التجريبي

To an ice-cooled, stirred solution of 5-Aminosalicylamide (10.0 grams, 0.073 tool), in 300 mL of water containing NaHCO3 (42.0 grams, 0.5 tool), iodoacetyl chloride (18.4 grams, 0.09 mol) is added dropwise over 15 min. After stirring at 0°-5° C. for 1 hr., the solution is acidified with cold 6N HCl. The precipitate is collected and dried in vacuo over NaOH pellets, to afford 21.3 grams (96% yield) of crude 5-(iodoacetamido)salicylamide.

المصدر