تفاعل #321333

معادلة التفاعل

hydrogen sulfide

( a )

Di-t-butyl [[4-[[[trans-4-cyanocyclohexyl]carbonyl -N-methylamino]acetyl]-o-phenylene]dioxy]diacetate

pyridine

triethylamine

→

thioamide

[[4-[[[trans-4-thiocarbamoylcyclohexyl]carbonyl-N-methylamino]acetyl]-o-phenylene]dioxy]diacetic acid

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 1 hour
2. 2
   درجة الحرارةAfter the reaction mixture was cooled to room temperature
3. 3
   غسيلwashed twice with each of a 5% aqueous sodium hydrogen carbonate
4. 4
   تجفيفAfter the organic layer was dried over anhydrous magnesium sulfate
5. 5
   أخرىthe inorganic salt was removed by filtration
6. 6
   تركيزThe filtrate was concentrated under reduced pressure
7. 7
   أخرىthe oily product thus obtained
8. 8
   أخرىwas purified by column chromatography on silica gel with an eluent system of chloroform

الإجراء التجريبي

Into the solution of the compound prepared in (a) (655 mg, 1.2 mmole) in the mixture of pyridine (15 ml) and triethylamine (1 ml) was streamed a hydrogen sulfide gas for 1 hour, and the mixture was stirred in a sealed tube at 50° C. for 5 hours. After the reaction mixture was cooled to room temperature, it was diluted with ethyl acetate, and washed twice with each of a 5% aqueous sodium hydrogen carbonate and a 1M potassium hydrogen sulfate solution. After the organic layer was dried over anhydrous magnesium sulfate, the inorganic salt was removed by filtration. The filtrate was concentrated under reduced pressure, and the oily product thus obtained was purified by column chromatography on silica gel with an eluent system of chloroform:methanol =50:1 to give 71 mg of the thioamide derivative as a yellow oily product (yield, 10%).

المصدر