تفاعل #321038

معادلة التفاعل

1,3-dibromopropane

3-acetamidophenol

potassium carbonate

→

3-(3-acetamidophenoxy)propyl bromide

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe resulting mixture was heated
2. 2
   درجة الحرارةat reflux for 6 hours
3. 3
   أخرىovernight
4. 4
   أخرىat room temperature
5. 5
   ترشيحSolids were filtered from the reaction mixture
6. 6
   تركيزthe solution was concentrated to an oil, which
7. 7
   أخرىwas purified

الإجراء التجريبي

To 3-acetamidophenol (15.1 g) in dichloromethane (500 ml, dry) was added potassium carbonate (20 g) and then 1,3-dibromopropane (30 g). The resulting mixture was heated at reflux for 6 hours and then overnight at room temperature. After an additional 24 hours, the reaction was complete. Solids were filtered from the reaction mixture, and the solution was concentrated to an oil, which was purified to yield 3-(3-acetamidophenoxy)propyl bromide, 13.2 g.

المصدر