تفاعل #319401

معادلة التفاعل

(4S)-4-phenylacetamido-3-isoxazolidinone

Compound ( 70 )

1-(4-nitrobenzyl) 3-(2-acetamidoethylthio)-2-oxoglutarate

1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

→

subject Compound ( 71 )

المردود 57.3%

4-nitrobenzyl 2-[(4S)-4-phenylacetamido-3-oxo-2-isoxazolidinyl]-3-(2acetamidoethylthio)-5-oxo-2-tetrahydrofurancarboxylate

المردود 57.3%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was evaporated off
2. 2
   غسيلfollowed by elution with ethyl acetate

الإجراء التجريبي

In 5 ml of dichloromethane were suspended 48 mg of (4S)-4-phenylacetamido-3-isoxazolidinone and 95 mg of the Compound (70) obtained in Example 70. To the suspension was added 71 mg of 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The mixture was stirred for 5.5 hours at room temperature. The solvent was evaporated off, and the residue was subjected to a silica gel column chromatography, followed by elution with ethyl acetate to give 75 mg of the subject Compound (71) as a colorless oily product.

المصدر